Laminin 332 in squamous-cell carcinoma

被引：242

作者：

Marinkovich, M. Peter ^{[1
]}

机构：

[1] VA Med Ctr, Palo Alto, CA USA

[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc2089

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Basement membranes can be a barrier to tumour growth, but basement membrane molecules, including laminins, are also important autocrine factors produced by cancers to promote tumorigenesis. Many studies have shown the importance of laminin 332 ( previously known as laminin 5) in this process, especially in squamous cell carcinoma. Through interactions with several cell- surface receptors ( including alpha 6 beta 4 and alpha 3 beta 1 integrins, epidermal growth factor receptor and syndecan 1) and other basement membrane components ( including type VII collagen), laminin 332 drives tumorigenesis through phosphatidylinositol- 3 kinase ( PI3K) and RAC1 activation, promoting tumour invasion and cell survival. The extracellular interactions of laminin 332 appear amenable to antibody- mediated therapies.

引用

页码：370 / 380

页数：11

共 109 条

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