ANCA Disease: Where Is This Field Heading?

被引：80

作者：

Falk, Ronald J. ^{[1
]}

Jennette, J. Charles ^{[1
]}

机构：

[1] Univ N Carolina, UNC Kidney Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 05期

关键词：

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; ANTIBODY-ASSOCIATED VASCULITIS; SMALL-VESSEL VASCULITIS; RANDOMIZED-TRIAL; WEGENERS-GRANULOMATOSIS; SYSTEMIC VASCULITIS; METHOTREXATE-MAINTENANCE; PULSE CYCLOPHOSPHAMIDE; DR; WEGENER; FRIEDRICH; ORAL CYCLOPHOSPHAMIDE;

D O I：

10.1681/ASN.2009121238

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

ANCA disease remains a subject of great experimental and clinical interest. The subcategories of names and descriptions for this collection of vasculitides and necrotizing glomerulonephritides is still a subject of some debate. The various forms of ANCA disease share some characteristics, and similar therapies are often recommended for overlapping categories of disease. The immunopathogenic effects of myeloperoxidase and proteinase 3 antibodies are well established, and good mechanisms for initiation of disease are starting to emerge, particularly the role of autoantigen complementarity. Here we examine these various topics and discuss an approach to treatment.

引用

页码：745 / 752

页数：8

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