ANCA Disease: Where Is This Field Heading?

被引：80

作者：

Falk, Ronald J. ^{[1
]}

Jennette, J. Charles ^{[1
]}

机构：

[1] Univ N Carolina, UNC Kidney Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 05期

关键词：

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; ANTIBODY-ASSOCIATED VASCULITIS; SMALL-VESSEL VASCULITIS; RANDOMIZED-TRIAL; WEGENERS-GRANULOMATOSIS; SYSTEMIC VASCULITIS; METHOTREXATE-MAINTENANCE; PULSE CYCLOPHOSPHAMIDE; DR; WEGENER; FRIEDRICH; ORAL CYCLOPHOSPHAMIDE;

D O I：

10.1681/ASN.2009121238

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

ANCA disease remains a subject of great experimental and clinical interest. The subcategories of names and descriptions for this collection of vasculitides and necrotizing glomerulonephritides is still a subject of some debate. The various forms of ANCA disease share some characteristics, and similar therapies are often recommended for overlapping categories of disease. The immunopathogenic effects of myeloperoxidase and proteinase 3 antibodies are well established, and good mechanisms for initiation of disease are starting to emerge, particularly the role of autoantigen complementarity. Here we examine these various topics and discuss an approach to treatment.

引用

页码：745 / 752

页数：8

共 69 条

[11] CLINICAL COURSE OF ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED GLOMERULONEPHRITIS AND SYSTEMIC VASCULITIS [J].

FALK, RJ ;

HOGAN, S ;

CAREY, TS ;

JENNETTE, JC .

ANNALS OF INTERNAL MEDICINE, 1990, 113 (09) :656-663

[12]

Franssen CFM, 1999, J AM SOC NEPHROL, V10, P1506

[13] WEGENER GRANULOMATOSIS AUTOANTIBODIES IDENTIFY A NOVEL DIISOPROPYLFLUOROPHOSPHATE BINDING-PROTEIN IN THE LYSOSOMES OF NORMAL HUMAN-NEUTROPHILS [J].

GOLDSCHMEDING, R ;

VANDERSCHOOT, CE ;

HUININK, DT ;

HACK, CE ;

VANDENENDE, ME ;

KALLENBERG, CGM ;

VONDEMBORNE, AEGK .

JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (05) :1577-1587

[14] Anti-Neutrophil Cytoplasmic Antibody Pathogenesis in Small-Vessel Vasculitis An Update [J].

Gomez-Puerta, Jose A. ;

Bosch, Xavier .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (05) :1790-1798

[15] A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis [J].

Guillevin, L ;

Cordier, JF ;

Lhote, F ;

Cohen, P ;

Jarrousse, B ;

Royer, I ;

Lesavre, P ;

Jacquot, C ;

Bindi, P ;

Bielefeld, P ;

Desson, JF ;

Détrée, F ;

Dubois, A ;

Hachulla, E ;

Hoen, B ;

Jacomy, D ;

Seigneuric, C ;

Lauque, D ;

Stern, M ;

Longy-Boursier, M .

ARTHRITIS AND RHEUMATISM, 1997, 40 (12) :2187-2198

[16] BIMODAL DISTRIBUTION OF PROTEINASE-3 (PR3) SURFACE EXPRESSION REFLECTS A CONSTITUTIVE HETEROGENEITY IN THE POLYMORPHONUCLEAR NEUTROPHIL POOL [J].

HALBWACHSMECARELLI, L ;

BESSOU, G ;

LESAVRE, P ;

LOPEZ, S ;

WITKOSARSAT, V .

FEBS LETTERS, 1995, 374 (01) :29-33

[17] Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro [J].

Hellmich, B ;

Csernok, E ;

Trabandt, A ;

Gross, WL ;

Ernst, M .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 120 (02) :392-398

[18]

Hiemstra T, 2009, APMIS, V117, P77

[19] TREATMENT OF WEGENERS GRANULOMATOSIS WITH INTERMITTENT HIGH-DOSE INTRAVENOUS CYCLOPHOSPHAMIDE [J].

HOFFMAN, GS ;

LEAVITT, RY ;

FLEISHER, TA ;

MINOR, JR ;

FAUCI, AS .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (04) :403-410

[20] Predictors of relapse and treatment resistance in antineutrophil cytoplasmic anti body-associated small-vessel vasculitis [J].

Hogan, SL ;

Falk, RJ ;

Chin, H ;

Cai, JW ;

Jennette, CE ;

Jennette, JC ;

Nachman, PH .

ANNALS OF INTERNAL MEDICINE, 2005, 143 (09) :621-631

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