Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer

被引:455
作者
Hervault, Aziliz [1 ,2 ]
Nguyen Thi Kim Thanh [1 ,2 ]
机构
[1] UCL Healthcare Biomagnet & Nanomat Labs, London W1S 4BS, England
[2] UCL, Dept Phys & Astron, London WC1E 6BT, England
关键词
IRON-OXIDE NANOPARTICLES; MRI CONTRAST ENHANCEMENT; CONTROLLED DRUG-DELIVERY; IN-VITRO; FLUID HYPERTHERMIA; MILD HYPERTHERMIA; BIOMEDICAL APPLICATIONS; FE3O4; NANOPARTICLES; MACROMOLECULAR THERAPEUTICS; POLYMERIC MICELLES;
D O I
10.1039/c4nr03482a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.
引用
收藏
页码:11553 / 11573
页数:21
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