Intra-arterial application of magnetic nanoparticles for targeted thrombolytic therapy: A rat embolic model

被引：28

作者：

Ma, Yunn-Hwa

Hsu, Ya-Wun

Chang, Yeu-Jhy

Hua, Mu-Yi

Chen, Jyh-Ping

Wu, Tony

机构：

[1] Chang Gung Mem Hosp, Dept Neurol, Tao Yuan, Taiwan

[2] Chang Gung Univ, Dept Physiol & Pharmacol, Tao Yuan, Taiwan

[3] Chang Gung Univ, Dept Chem & Mat Engn, Tao Yuan, Taiwan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

magnetic nanoparticle; targeted drug delivery; thrombolysis; tissue plasminogen activator; nanomedicine; thromboembolic disease;

D O I：

10.1016/j.jmmm.2006.10.1204

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Targeted delivery of thrombolytic drug to the site of emboli exhibits potential to greatly reduce hemorrhagic side effect. A rat embolic model with an easy access of a magnet was established for study of the efficacy of magnetic drug targeting. In anesthetized rats, a whole blood clot produced in vitro was injected from the right iliac artery and lodged in the left iliac artery. Intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA) thereafter significantly reversed the iliac flow within 15 min. Placement of an NdFeB magnet above the left iliac artery caused magnetic nanoparticle retention against hemodynamic dragging force in the presence and absence of the clot. Our results suggest the feasibility of this rat embolic model for the study of magnetic targeted delivery of thrombolytic drugs. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：342 / 346

页数：5

共 12 条

[1] Guidelines for the early management of patients with ischemic stroke - A scientific statement from the Stroke Council of the American Stroke Association [J].