(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide:: The first selective 5-HT7 receptor antagonist

被引:106
作者
Forbes, IT
Dabbs, S
Duckworth, DM
Jennings, AJ
King, FD
Lovell, PJ
Brown, AM
Collin, L
Hagan, JJ
Middlemiss, DN
Riley, GJ
Thomas, DR
Upton, N
机构
[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AW, Essex, England
[2] SmithKline Beecham Pharmaceut, Dept Neurosci Res, Harlow CM19 5AW, Essex, England
关键词
D O I
10.1021/jm970519e
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:655 / 657
页数:3
相关论文
共 21 条
[1]  
BARD JA, 1993, J BIOL CHEM, V268, P23422
[2]  
Branchek T. A., 1994, British Journal of Pharmacology, V112, p100P
[3]  
Cushing DJ, 1996, J PHARMACOL EXP THER, V277, P1560
[4]   The 5-HT7 receptor: Orphan found [J].
Eglen, RM ;
Jasper, JR ;
Chang, DJ ;
Martin, GR .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (04) :104-107
[5]   A receptor autoradiographic and in situ hybridization analysis of the distribution of the 5-ht(7) receptor in rat brain [J].
Gustafson, EL ;
Durkin, MM ;
Bard, JA ;
Zgombick, J ;
Branchek, TA .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (04) :657-666
[6]  
Heidmann DEA, 1997, J NEUROCHEM, V68, P1372
[7]  
Jasper JR, 1997, BRIT J PHARMACOL, V120, pP298
[8]   Characterization of putative 5-ht(7) receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein [J].
Leung, E ;
Walsh, LKM ;
PulidoRios, MT ;
Eglen, RM .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (05) :926-930
[9]   A NOVEL ADENYLYL CYCLASE-ACTIVATING SEROTONIN RECEPTOR (5-HT7) IMPLICATED IN THE REGULATION OF MAMMALIAN CIRCADIAN-RHYTHMS [J].
LOVENBERG, TW ;
BARON, BM ;
DELECEA, L ;
MILLER, JD ;
PROSSER, RA ;
REA, MA ;
FOYE, PE ;
RACKE, M ;
SLONE, AL ;
SIEGEL, BW ;
DANIELSON, PE ;
SUTCLIFFE, JG ;
ERLANDER, MG .
NEURON, 1993, 11 (03) :449-458
[10]  
MARTIN GR, 1995, BRIT J PHARMACOL, V114, pP383