Biophysical analyses of designed and selected mutants of protocatechuate 3,4-dioxyogenase

被引：20

作者：

Brown, CK ^{[1
]}

Vetting, MW

Earhart, CA

Ohlendorf, DH

机构：

[1] Ctr Met Biocatalysis, Minneapolis, MN 55455 USA

[2] Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

[3] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2004年 / 58卷

关键词：

catechol; protocatechuate; dioxygenase; metalloenzyme; iron; crystallography;

D O I：

10.1146/annurev.micro.57.030502.090927

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The catechol dioxygenases allow a wide variety of bacteria to use aromatic compounds as carbon sources by catalyzing the key ring-opening step. These enzymes use specifically either catechol or protocatechuate (2,3-dihydroxybenozate) as their substrates; they use a bare metal ion as the sole cofactor. To learn how this family of metalloenzymes functions, a structural analysis of designed and selected mutants of these enzymes has been undertaken. Here we review the results of this analysis on the nonheme ferric iron intradiol dioxygenase protocatechuate 3,4-dioxygenase.

引用

页码：555 / 585

页数：39

共 117 条

[1]

ARCIERO DM, 1983, J BIOL CHEM, V258, P4981

[2] MICROBIAL-DEGRADATION OF PHLOROGLUCINOL AND OTHER POLYPHENOLIC COMPOUNDS [J].

ARMSTRONG, SM ;

PATEL, TR .

JOURNAL OF BASIC MICROBIOLOGY, 1994, 34 (02) :123-135

[3]

ASTURIAS JA, 1994, J BIOL CHEM, V269, P7807

[4] Phthalates in paper and board packaging and their migration into Tenax and sugar [J].

Aurela, B ;

Kulmala, H ;

Söderhjelm, L .

FOOD ADDITIVES AND CONTAMINANTS, 1999, 16 (12) :571-577

[5] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[6] Catechol dioxygenases [J].

Broderick, JB .

ESSAYS IN BIOCHEMISTRY, VOL 34, 1999, 1999, 34 :173-189

[7] Key aromatic-ring-cleaving enzyme, protocatechuate 3,4-dioxygenase, in the ecologically important marine Roseobacter lineage [J].

Buchan, A ;

Collier, LS ;

Neidle, EL ;

Moran, MA .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (11) :4662-4672

[8] Exploring the catalytic mechanism of the extradiol catechol dioxygenases [J].

Bugg, TDH ;

Sanvoisin, J ;

Spence, EL .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1997, 25 (01) :81-85

[9]

Bugg TDH, 1998, NAT PROD REP, V15, P513

[10]

BULL C, 1981, J BIOL CHEM, V256, P2681

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