Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

被引：155

作者：

Kitano, Hideto ^{[1
]}

Kirsch, Jeffrey R. ^{[1
]}

Hurn, Patricia D. ^{[1
]}

Murphy, Stephanie J. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Anesthesia & Perioperat Med, Portland, OR 97239 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2007年 / 27卷 / 06期

关键词：

inhalational anesthesia; neuroprotection; perioperative stroke; preconditioning;

D O I：

10.1038/sj.jcbfm.9600410

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

引用

页码：1108 / 1128

页数：21

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