Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

被引：155

作者：

Kitano, Hideto ^{[1
]}

Kirsch, Jeffrey R. ^{[1
]}

Hurn, Patricia D. ^{[1
]}

Murphy, Stephanie J. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Anesthesia & Perioperat Med, Portland, OR 97239 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2007年 / 27卷 / 06期

关键词：

inhalational anesthesia; neuroprotection; perioperative stroke; preconditioning;

D O I：

10.1038/sj.jcbfm.9600410

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

引用

页码：1108 / 1128

页数：21

共 163 条

[31] Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices [J].

Eilers, H ;

Bickler, PE .

ANESTHESIOLOGY, 1996, 85 (03) :600-607

[32] Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat [J].

Elsersy, H ;

Sheng, HX ;

Lynch, JR ;

Moldovan, M ;

Pearlstein, RD ;

Warner, DS .

ANESTHESIOLOGY, 2004, 100 (05) :1160-1166

[33] Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats [J].

Engelhard, K ;

Werner, C ;

Reeker, W ;

Lu, H ;

Möllenberg, O ;

Mielke, L ;

Kochs, E .

BRITISH JOURNAL OF ANAESTHESIA, 1999, 83 (03) :415-421

[34] Sevoflurane and propofol influence the expression of apoptosis-regulating proteins after cerebral ischaemia and reperfusion in rats [J].

Engelhard, K ;

Werner, C ;

Eberspächer, E ;

Pape, M ;

Blobner, M ;

Hutzler, P ;

Kochs, E .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2004, 21 (07) :530-537

[35] The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats [J].

Engelhard, K ;

Werner, C ;

Hoffman, WE ;

Matthes, B ;

Blobner, M ;

Kochs, E .

ANESTHESIA AND ANALGESIA, 2003, 97 (04) :1155-1161

[36] The North American Symptomatic Carotid Endarterectomy Trial - Surgical results in 1415 patients [J].

Ferguson, GG ;

Eliasziw, M ;

Barr, HWK ;

Clagett, GP ;

Barnes, RW ;

Wallace, MC ;

Taylor, DW ;

Haynes, RB ;

Finan, JW ;

Hachinski, VC ;

Barnett, HJM .

STROKE, 1999, 30 (09) :1751-1758

[37] Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil [J].

Gassmayr, S ;

Stadnicka, A ;

Suzuki, A ;

Kwok, WM ;

Bosnjak, ZJ .

ANESTHESIOLOGY, 2003, 98 (01) :114-120

[38] PRIMATE BRAIN TOLERANCE TO TEMPORARY FOCAL CEREBRAL-ISCHEMIA DURING ISOFLURANE-INDUCED OR SODIUM NITROPRUSSIDE-INDUCED HYPOTENSION [J].

GELB, AW ;

BOISVERT, DP ;

TANG, C ;

LAM, AM ;

MARCHAK, BE ;

DOWMAN, R ;

MIELKE, BW .

ANESTHESIOLOGY, 1989, 70 (04) :678-683

[39] PROLONGED IMMOBILIZATION AND CONTROLLED VENTILATION DO NOT IMPROVE OUTCOME AFTER GLOBAL BRAIN ISCHEMIA IN MONKEYS [J].

GISVOLD, SE ;

SAFAR, P ;

RAO, G ;

MOOSSY, J ;

BRON, K ;

ALEXADER, H .

CRITICAL CARE MEDICINE, 1984, 12 (03) :171-179

[40] Programmed cell death in cerebral ischemia [J].

Graham, SH ;

Chen, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (02) :99-109

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