Chemokines in joint disease: the key to inflammation?

被引：109

作者：

Haringman, JJ ^{[1
]}

Ludikhuize, J ^{[1
]}

Tak, PP ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2004年 / 63卷 / 10期

关键词：

D O I：

10.1136/ard.2004.020529

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Targeting chemokines and/or chemokine receptors appears to be an intriguing new approach to treating chronic inflammatory disorders like rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and transplant rejections. The involvement of chemokines and chemokine receptors in inflammatory joint diseases, the in vitro and in vivo characteristics of the chemokine family in inflammatory joint disease, and initial clinical data on chemokine blockade in patients with rheumatoid arthritis suggest that targeting the chemokine and chemokine receptor family might provide a new, promising antirheumatic strategy.

引用

页码：1186 / 1194

页数：9

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