[Gd-AAZTA]-:: A new structural entry for an improved generation of MRI contrast agents

被引：188

作者：

Aime, S

Calabi, L

Cavallotti, C

Gianolio, E

Giovenzana, GB

Losi, P

Maiocchi, A

Palmisano, G

Sisti, M

机构：

[1] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

[2] Bracco Imaging SpA, I-20135 Milan, Italy

[3] Univ Piemonte Orientale A Avogadro, Dippartimento Sci Chim Alimentari Farmaceut & Far, I-28100 Novara, Italy

[4] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

INORGANIC CHEMISTRY | 2004年 / 43卷 / 24期

关键词：

D O I：

10.1021/ic0489692

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)](-) shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.

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页码：7588 / 7590

页数：3

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