Chronic social defeat stress disrupts regulation of lipid synthesis

被引：95

作者：

Chuang, Jen-Chieh ^{[1
]}

Cui, Huxing ^{[1
,2
]}

Mason, Brittany L. ^{[2
]}

Mahgoub, Melissa ^{[2
]}

Bookout, Angie L. ^{[1
,4
]}

Yu, Hana G. ^{[2
]}

Perello, Mario ^{[1
]}

Elmquist, Joel K. ^{[1
,2
,4
]}

Repa, Joyce J. ^{[1
,3
]}

Zigman, Jeffrey M. ^{[1
,2
]}

Lutter, Michael ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

来源：

JOURNAL OF LIPID RESEARCH | 2010年 / 51卷 / 06期

关键词：

anxiety; cholesterol; depression feeding; liver; METABOLIC SYNDROME; LIPOPROTEIN RECEPTOR; LDL-RECEPTOR; MAJOR DEPRESSION; EXCESS MORTALITY; MOUSE-LIVER; CHOLESTEROL; DISORDER; PROTEIN; EXPRESSION;

D O I：

10.1194/jlr.M002196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several psychiatric disorders increase the risk of cardiovascular disease, including posttraumatic stress disorder and major depression. While the precise mechanism for this association has not yet been established, it has been shown that certain disorders promote an unfavorable lipid profile. To study the interaction of stress and lipid dysregulation, we utilized chronic social defeat stress (CSDS), a mouse model of chronic stress with features of posttraumatic stress disorder and major depression. Following exposure to CSDS, mice were given access to either regular chow or a Western-style diet high in fat and cholesterol (HFD). The combination of social stress and HFD resulted in significant perturbations in lipid regulation, including two key features of the metabolic syndrome: increased plasma levels of non-HDL cholesterol and intrahepatic accumulation of triglycerides. These effects were accompanied by a number of changes in the expression of hepatic genes involved in lipid regulation. Transcriptional activity of LXR, SREBP1c, and ChREBP were significantly affected by exposure to HFD and CSDS. We present CSDS as a model of social stress induced lipid dysregulation and propose that social stress alters lipid metabolism by increasing transcriptional activity of genes involved in lipid synthesis.-Chuang, J-C., H. Cui, B. L. Mason, M. Mahgoub, A. L. Bookout, H. G. Yu, M. Perello, J. K. Elmquist, J. J. Repa, J. M. Zigman, and M. Lutter. Chronic social defeat stress disrupts regulation of lipid synthesis. J. Lipid Res. 2010. 51: 1344-1353.

引用

页码：1344 / 1353

页数：10