The birth process initiates an acute phase reaction in the fetus-newborn infant

被引:73
作者
Marchini, G
Berggren, V
Djilali-Merzoug, R
Hansson, LO
机构
[1] Karolinska Hosp, Karolinska Inst, Dept Woman & Child Hlth, SE-17176 Stockholm, Sweden
[2] Karolinska Hosp, Karolinska Inst, Dept Lab Med, SE-17176 Stockholm, Sweden
[3] Karolinska Hosp, Karolinska Inst, Dept Clin Chem, SE-17176 Stockholm, Sweden
关键词
acute-phase protein; infant; interleukin;
D O I
10.1080/713794557
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Our goal was to investigate whether the normal birth process stimulated an acute phase response in healthy infants with physiological changes in the circulating levels of acute phase cytokines and acute phase proteins. We also monitored body temperature, body weight and behavioural state in order to investigate if clinical signs of acute phase reaction were present. We made cross-sectional measurements of interleukin-1 beta, interleukin-6, C-reactive protein, serum amyloid A, procalcitonin, prealbumin, body weight, body temperature and the duration of the sleeping period during the first four postnatal days. We found an increase in interleukin-6 (p < 0.001) during the first day, followed by an increase in C-reactive protein, serum amyloid A and procalcitonin on the second postnatal day (p < 0.01). The level of prealbumin fell after birth and reached its lowest value at 3 d of age (p < 0.001). Interleukin-1 beta remained unchanged. The duration of the sleeping period was longer during the first day (p < 0.01). There was an increase in body temperature during the first day (p < 0.01). Maximal weight loss was during the first 2 d. Conclusions: The normal birth process and extra-uterine adaptation stimulates an acute phase reaction in the newborn infant with a release of interleukin-6 and acute phase proteins and a depression of prealbumin. This reaction, as the body's first line inflammatory defence system, probably affects: the infant's behaviour, nutritional state as well as the regulation of body temperature.
引用
收藏
页码:1082 / 1086
页数:5
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