Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation

被引：164

作者：

Goodrich, James A. ^{[3
]}

Tjian, Robert ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[3] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 08期

关键词：

RNA-POLYMERASE-II; PROTEIN-RELATED FACTOR; TBP-LIKE FACTOR; MICE LACKING; CHROMATIN CONDENSATION; EMBRYONIC-DEVELOPMENT; HISTONE MODIFICATIONS; GAL4; DERIVATIVES; GERM-CELLS; ACTIVATOR;

D O I：

10.1038/nrg2847

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with 'non-prototypical' subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.

引用

页码：549 / 558

页数：10

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