Water dynamics in human blood via combined measurements of T2 relaxation and diffusion in the presence of gadolinium

被引：75

作者：

Stanisz, GJ ^{[1
]}

Li, JG ^{[1
]}

Wright, GA ^{[1
]}

Henkelman, RM ^{[1
]}

机构：

[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, N York, ON M4N 3M5, Canada

来源：

MAGNETIC RESONANCE IN MEDICINE | 1998年 / 39卷 / 02期

关键词：

D O I：

10.1002/mrm.1910390209

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

An analytical model of tissue relaxation and restricted diffusion in human blood is presented. The brood tissue model is composed of three different compartments: red blood cells, plasma, and macromolecular protons. The relaxation rate constants and free diffusion coefficients of intracellular and extracellular water may differ, Analytical formulas for signal loss due to relaxation and diffusion in the Carr-Purcell Meiboom-Gill and pulsed-field-gradient multispin echo experiments for this tissue model are derived. The model is fitted to the experimental data for human blood with various concentrations of Gadolinium contrast agent. The obtained model parameters are realistic. The validity and sensitivity of the model are also discussed.

引用

页码：223 / 233

页数：11