Chemical and enzymatic synthesis of glycoconjugates 3: Synthesis of lactosamine by thermophilic galactosidase catalyzed galactosylation on a multigram scale

被引：25

作者：

Fang, JW ^{[1
]}

Xie, WH ^{[1
]}

Li, J ^{[1
]}

Wang, PG ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10676-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of thermophilic glycosidases was screened for lactosamine preparation from a transgalactosylation reaction between lactose and glucosamine hydrochloride. Two enzymes showed excellent regioselectivity toward glucosamine hydrochloride. The product could be synthesized on a multigram scale and was easily separated and purified by subsequently eluting through cation and anion exchange resin columns. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：919 / 922

页数：4

共 20 条

[1] Enzymes from microorganisms in extreme environments
Adams, MWW
Kelly, RM
[J]. CHEMICAL & ENGINEERING NEWS, 1995, 73 (51) : 32 - 42
[2] ALAIS J, 1983, TETRAHEDRON LETT, P5223
[3] BRENNAN MB, 1996, CHEM ENG NEWS 1014, P31
[4] THE ADHESIVE SPECIFICITY OF THE SOLUBLE HUMAN LECTIN, IGE-BINDING PROTEIN, TOWARD LIPID-LINKED OLIGOSACCHARIDES - PRESENCE OF THE BLOOD GROUP-A, GROUP-B, GROUP-B-LIKE, AND GROUP-H MONOSACCHARIDES CONFERS A BINDING-ACTIVITY TO TETRASACCHARIDE (LACTO-N-TETRAOSE AND LACTO-N-NEOTETRAOSE) BACKBONES
FEIZI, T
SOLOMON, JC
YUEN, CT
JENG, KCG
FRIGERI, LG
HSU, DK
LIU, FT
[J]. BIOCHEMISTRY, 1994, 33 (20) : 6342 - 6349
[5] HERRMANN GF, 1992, J AM CHEM SOC, V114, P9283
[6] A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and beta-galactosidase
Kimura, T
Takayama, S
Huang, HM
Wong, CH
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (20): : 2348 - 2350
[7] LI J, 1997, IN PRESS TETRAHEDRON
[8] PRODUCTION OF GLUCOSAMINE CONTAINING DISACCHARIDES OF THE LEWIS-A AND LEWIS-X TYPES EMPLOYING GLYCOSIDASES
NILSSON, KGI
ELIASSON, A
LARSSONFOREK, U
[J]. BIOTECHNOLOGY LETTERS, 1995, 17 (07) : 717 - 722
[9] ROBERTSON DE, 1996, SIM NEWS, V46, P3
[10] NEW METHODS FOR THE SYNTHESIS OF GLYCOSIDES AND OLIGOSACCHARIDES - ARE THERE ALTERNATIVES TO THE KOENIGS-KNORR METHOD
SCHMIDT, RR
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (03): : 212 - 235

← 1 2 →