Discovery of a new class of p38 kinase inhibitors

被引：60

作者：

Dumas, J

Sibley, R

Riedl, B

Monahan, MK

Lee, W

Lowinger, TB

Redman, AM

Johnson, JS

Kingery-Wood, J

Scott, WJ

Smith, RA

Bobko, M

Schoenleber, R

Ranges, GE

Housley, TJ

Bhargava, A

Wilhelm, SM

Shrikhande, A

机构：

[1] Bayer Res Ctr, Dept Chem Res, W Haven, CT 06516 USA

[2] Bayer Res Ctr, Dept Canc Osteoporosis Res, W Haven, CT 06516 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)00270-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel small-molecule inhibitors of p38 kinase were derived from a combinatorial chemistry effort and exhibit activity in the nanomolar range. Very steep structure-activity relationships are observed within this class. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2047 / 2050

页数：4

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