A total synthesis of mycophenolic acid

被引：21

作者：

Covarrubias-Zúñiga, A ^{[1
]}

González-Lucas, A ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Coyoacan 04510, Mexico

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(98)00423-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total convergent synthesis of mycophenolic acid 1 from 2-geranyl-dimethyl-1,3-acetonedicarboxylate 2 and 4-pivaloyloxy-2-butynal using a Michael addition-Dieckmann cyclization as key step is described. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2881 / 2882

页数：2

共 14 条

[1] BIRCH AJ, 1969, J AUST J CHEM, V22, P2365
[2] TOTAL SYNTHESIS OF MYCOPHENOLIC ACID, SOME ANALOGS AND SOME BIOGENETIC INTERMEDIATES
CANONICA, L
RINDONE, B
SCOLASTICO, C
SANTANIELLO, E
[J]. TETRAHEDRON, 1972, 28 (16) : 4395 - +
[3] A convenient one-pot method for the construction of tetrasubstituted phenols through a Michael addition aldol cyclization sequence
CovarrubiasZuniga, A
RiosBarrios, E
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (17) : 5688 - 5689
[4] TOTAL SYNTHESIS OF MYCOPHENOLIC-ACID
DANHEISER, RL
GEE, SK
PEREZ, JJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (04) : 806 - 810
[5] Total synthesis of mycophenolic acid
delaCruz, RA
Talamas, FX
Vazquez, A
Muchowski, JM
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1997, 75 (06): : 641 - 645
[6] THE ACTION OF MYCOPHENOLIC-ACID ON CANDIDA-ALBICANS
GALLAGHER, JA
QUINN, CM
WHITTAKER, PA
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1987, 15 (02) : 290 - 290
[7] Gosio B., 1896, RIV IGIENE SANITA PU, V7, P869
[8] GOSIO B, 1896, RIV IGIENE SANITA PU, V7, P961
[9] KNUDTZON S, 1987, J AM ACAD DERMATOL, V17, P962
[10] IMMUNOSUPPRESSIVE EFFECT OF MYCOPHENOLIC ACID
MITSUI, A
SUZUKI, S
[J]. JOURNAL OF ANTIBIOTICS, 1969, 22 (08) : 358 - &

← 1 2 →