Heterochromatin: Proteins in flux lead to stable repression

被引：10

作者：

Kamakaka, RT ^{[1
]}

机构：

[1] NICHD, Unit Chromatin & Transcript, NIH, Bethesda, MD 20892 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(03)00236-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heterochromatin is a phenotypically stable entity, but recent studies on the binding of HP1 protein in heterochromatin indicate that the individual components within these domains are not stably bound but in constant flux. These results force us to reexamine previous models of heterochromatin.

引用

页码：R317 / R319

页数：3

共 20 条

[1] The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly
Ahmad, K
Henikoff, S
[J]. MOLECULAR CELL, 2002, 9 (06) : 1191 - 1200
[2] Histone methylation: Dynamic or static?
Bannister, AJ
Schneider, R
Kouzarides, T
[J]. CELL, 2002, 109 (07) : 801 - 806
[3] Dynamic behavior of transcription factors on a natural promoter in living cells
Becker, M
Baumann, C
John, S
Walker, DA
Vigneron, M
McNally, JG
Hager, GL
[J]. EMBO REPORTS, 2002, 3 (12) : 1188 - 1194
[4] Maintenance of stable heterochromatin domains by dynamic HP1 binding
Cheutin, T
McNairn, AJ
Jenuwein, T
Gilbert, DM
Singh, PB
Misteli, T
[J]. SCIENCE, 2003, 299 (5607) : 721 - 725
[5] Breaking through to the other side: silencers and barriers
Dhillon, N
Kamakaka, RT
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) : 188 - 192
[6] Unravelling heterochromatin: competition between positive and negative factors regulates accessibility
Dillon, N
Festenstein, R
[J]. TRENDS IN GENETICS, 2002, 18 (05) : 252 - 258
[7] A kinetic framework for a mammalian RNA polymerase in vivo
Dundr, M
Hoffmann-Rohrer, U
Hu, QY
Grummt, I
Rothblum, LI
Phair, RD
Misteli, T
[J]. SCIENCE, 2002, 298 (5598) : 1623 - 1626
[8] The HP1 protein family: getting a grip on chromatin
Eissenberg, JC
Elgin, SCR
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (02) : 204 - 210
[9] PRESENCE OF HISTONE-H1 ON AN ACTIVE BALBIANI RING GENE
ERICSSON, C
GROSSBACH, U
BJORKROTH, B
DANEHOLT, B
[J]. CELL, 1990, 60 (01) : 73 - 83
[10] Modulation of heterochromatin protein 1 dynamics in primary mammalian cells
Festenstein, R
Pagakis, SN
Hiragami, K
Lyon, D
Verreault, A
Sekkali, B
Kioussis, D
[J]. SCIENCE, 2003, 299 (5607) : 719 - 721

← 1 2 →