Rotavirus vaccines - an update

被引：14

作者：

Kirkwood, CD

Buttery, J

机构：

[1] Univ Melbourne, Enteric Virus Res Grp, Dept Gastroenterol & Clin Nutr,Dept Paediat, Murdoch Childrens Res Inst,Royal Childrens Hosp, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp, Clin Paediat Infect Dis Unit, Parkville, Vic 3052, Australia

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2003年 / 3卷 / 01期

关键词：

immunisation; rotavirus; rotavirus vaccine; vaccine;

D O I：

10.1517/14712598.3.1.97

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rotavirus vaccines offer the best hope to reduce the toll of acute rotaviral gastroenteritis in both developed and developing countries. An association with intussusception (IS) led to the withdrawal of the first licensed rotavirus vaccine in the USA in 1999, forcing a re-evaluation of the safety profile of potentially lifesaving vaccines. Development of new rotavirus vaccine candidates has continued, with a bovine-human reassortant vaccine and an attenuated human monovalent vaccine commencing Phase III trials. Several other candidates are in early Phase I and II clinical trials. The creation of innovative funding strategies to support vaccine development and production, specifically in developing countries, aim to make vaccines available where rotavirus causes the greatest impact.

引用

页码：97 / 105

页数：9

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