Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia

被引：20

作者：

Fermo, E

Bianchi, P

Barcellini, W

Pedotti, P

Boschetti, C

Alfinito, F

Cortelezzi, A

Zanella, A

机构：

[1] Osped Maggiore, IRCCS, Div Ematol, I-20122 Milan, Italy

[2] Univ Naples Federico II, Div Haematol, Naples, Italy

[3] Univ Milan, Dept Med Sci, Milan, Italy

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 2004年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.1365-2370.2004.00480.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated regulatory variants of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 40 Italian patients affected by paroxysmal nocturnal haemoglobinuria (PNH) and aplastic anaemia (AA). Genotypes associated with high production of TGF-beta and IFN-gamma were more frequent in patients than in controls. Genetic regulation of the immunological pathways involved in the pathogenesis of bone marrow failure is suggested.

引用

页码：267 / 269

页数：3

共 22 条

[1] Genotypic variation in the transforming growth factor-β1 gene -: Association with transforming growth factor-pi production, fibrotic lung disease, and graft fibrosis after lung transplantation [J].