De novo infection in a renal transplant recipient caused by novel mutants of hepatitis B virus despite the presence of protective anti-hepatitis B surface antibody

被引：27

作者：

Lu, MG ^{[1
]}

Lorentz, T ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Virol, D-45122 Essen, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 187卷 / 08期

关键词：

D O I：

10.1086/373902

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

A renal transplant recipient became persistently positive for hepatitis B virus (HBV) despite preexisting anti-hepatitis B surface (HBs) antibodies. The antigenicity and immunogenicity of wild-type (wt) and mutant HBs antigens (Ags) were compared. In contrast to wt HBsAg, genetic vaccination with mutant HBsAgs did not induce anti-HBs. Thus, mutations within HBsAg may enable HBV to escape immunological control.

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页码：1323 / 1326

页数：4

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