GENETIC RELATEDNESS OF HEPATITIS-B VIRAL STRAINS OF DIVERSE GEOGRAPHICAL ORIGIN AND NATURAL VARIATIONS IN THE PRIMARY STRUCTURE OF THE SURFACE-ANTIGEN

被引:304
作者
NORDER, H
HAMMAS, B
LEE, SD
BILE, K
COUROUCE, AM
MUSHAHWAR, IK
MAGNIUS, LO
机构
[1] NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN
[2] VET GEN HOSP,DEPT MED,TAIPEI,TAIWAN
[3] INST NATL TRANSFUS SANGUINE,F-75739 PARIS,FRANCE
[4] ABBOTT LABS,EXPTL BIOL RES,N CHICAGO,IL 60064
关键词
D O I
10.1099/0022-1317-74-7-1341
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A 681 nucleotide fragment of the hepatitis B virus (HBV) genome was sequenced that corresponded to the complete gene for hepatitis B surface antigen (HBsAg) in 80 HBsAg- and hepatitis B e antigen (HBeAg)-positive sera of diverse geographical origins. These and 42 previously published HBV sequences within the S gene were used for th e construction of a dendrogram. In this comparison, each of the 122 HBsAg genes was found to be related to one or other of the six previously identified genomic groups of HBV, A to F. The HBV strains within each genomic group showed a characteristic geographical distribution. Group A genomes were represented by 23 strains mainly originating in northern Europe and sub-Saharan Africa. The group B and C genomes, represented by 17 and 28 strains respectively, were confined to populations with origins in eastern Asia and the Far East. The group D genomes, represented by 38 strains, were found worldwide, but were the predominant strains in the Mediterranean area, the Near and Middle East, and in south Asia. Group E genomes, represented by nine strains, were indigenous to western sub-Saharan Africa as far south as Angola. There were indications that the F group, made up of six strains, represented the genomic group of HBV among populations with origins in the New World. Thus, HBV has diverged into genomic groups according to the distribution of mankind in the different continents. As well as giving information on the genetic relationship of HBV strains of different geographical origin, this study also provides information on the primary structure of HBsAg in different regions of the world. Such data might prove valuable in explaining the reported failures to obtain protection with current HBV vaccines.
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页码:1341 / 1348
页数:8
相关论文
共 45 条
  • [1] SUBTYPE AYW VARIANT OF HEPATITIS-B VIRUS - DNA PRIMARY STRUCTURE-ANALYSIS
    BICHKO, V
    PUSHKO, P
    DREILINA, D
    PUMPEN, P
    GREN, E
    [J]. FEBS LETTERS, 1985, 185 (01) : 208 - 212
  • [2] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS
    CARMAN, WF
    ZANETTI, AR
    KARAYIANNIS, P
    WATERS, J
    MANZILLO, G
    TANZI, E
    ZUCKERMAN, AJ
    THOMAS, HC
    [J]. LANCET, 1990, 336 (8711) : 325 - 329
  • [3] CASTILLO D, 1979, REV MED CHILE, V107, P373
  • [4] COUROUCE AM, 1976, BIBL HAEMATOL, V42, P1
  • [5] NEW HEPATITIS-B SURFACE-ANTIGEN SUBTYPES INSIDE AD CATEGORY
    COUROUCEPAUTY, AM
    LEMAIRE, JM
    ROUX, JF
    [J]. VOX SANGUINIS, 1978, 35 (05) : 304 - 308
  • [6] DISTRIBUTION OF HBSAG SUBTYPES IN THE WORLD
    COUROUCEPAUTY, AM
    PLANCON, A
    SOULIER, JP
    [J]. VOX SANGUINIS, 1983, 44 (04) : 197 - 211
  • [7] COURSAGET P, 1987, LANCET, V2, P1354
  • [8] NUCLEOTIDE-SEQUENCE OF A HEPATITIS-B VIRUS GENOME OF SUBTYPE ADW ISOLATED FROM A FILIPINO - COMPARISON WITH THE REPORTED 3 GENOMES OF THE SAME SUBTYPE
    ESTACIO, RC
    CHAVEZ, CC
    OKAMOTO, H
    LINGAO, AL
    REYES, MT
    DOMINGO, E
    MAYUMI, M
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1988, 3 (03) : 215 - 222
  • [9] CLONING AND STRUCTURAL-ANALYSES OF HEPATITIS-B VIRUS DNAS, SUBTYPE ADR
    FUJIYAMA, A
    MIYANOHARA, A
    NOZAKI, C
    YONEYAMA, T
    OHTOMO, N
    MATSUBARA, K
    [J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (13) : 4601 - 4610
  • [10] NUCLEOTIDE-SEQUENCE OF THE HEPATITIS-B VIRUS GENOME (SUBTYPE AYW) CLONED IN ESCHERICHIA-COLI
    GALIBERT, F
    MANDART, E
    FITOUSSI, F
    TIOLLAIS, P
    CHARNAY, P
    [J]. NATURE, 1979, 281 (5733) : 646 - 650