Notch signalling at the crossroads of T cell development and leukemogenesis

被引：18

作者：

Campese, AF

Bellavia, D

Gulino, A

Screpanti, I

机构：

[1] Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Ist Pasteur, Fondaz Cenci Bolognetti Fdn, I-00161 Rome, Italy

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 02期

关键词：

leukaemia; NF kappa B; notch; pre-TCR; thymus;

D O I：

10.1016/S1084-9521(02)00184-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Members of the Notch family (e.g. Notch l and Notch3) have been recently described to play a critical role in T cell development and their constitutive activation has been related to T cell leukaemia in both animal models and human disease. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or leukemogenesis is not clear. Altered Notch signalling impairs the developmentally-regulated interplay between pre-TCR signalling, NFKB and E2A activities, thus identifying the crucial role of Notch receptors at the cross-roads of disrupted lymphoid differentiation and neoplastic transformation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：151 / 157

页数：7

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