Immunologic and inflammatory mediators and cognitive decline in Alzheimer's disease

被引：14

作者：

Ahluwalia, N

Vellas, B

机构：

[1] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA

[2] Toulouse Univ Hosp, Toulouse Alzheimers Ctr, Dept Med, F-31300 Toulouse, France

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2003年 / 23卷 / 01期

关键词：

D O I：

10.1016/S0889-8561(02)00048-6

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Local up-regulation of immune mediators is involved as a secondary or tertiary event in the development of Alzheimer's disease (AD); however, the systemic cell-mediated immune response in patients with AD may be impaired. Several factors, including malnutrition, may be involved in the reduced immune response in advanced stages of AD. A better understanding of the immune mediators that are involved in the local and systemic immune response in AD may assist in mediating the development of AD, halting its progression, and treating patients with effective anti-inflammatory drugs and immunization strategies.

引用

页码：103 / +

页数：14

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