Phosphoinositide 3-kinase signalling events controlling axonal morphogenesis

被引：42

作者：

Cosker, K. E. ^{[1
]}

Eickholt, B. J. ^{[1
]}

机构：

[1] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

基金：

英国医学研究理事会;

关键词：

axonal morphogenesis; GTPase; neuronal morphology; neurotrophin; phosphoinositide 3-kinase (PI3K); signalling;

D O I：

10.1042/BST0350207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The establishment of neuronal morphology is essential for the formation of the nervous system. In general, neurons undergo a developmental programme during which their immature processes are specified into one axon and several dendrites. Extension of axons and dendrites is then critical for the establishment of appropriate connectivity. A body of work implicates the PI3K (phosphoinositide 3-kinase) signalling pathway to be crucial during the various events leading to the formation of neuronal circuit. In this review, we will focus specifically on the function of PI3K and downstream signalling cascades that control the establishment of axonal specification and elongation.

引用

页码：207 / 210

页数：4

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