Apoptosis in hematological disorders

被引：33

作者：

Debatin, KM ^{[1
]}

Stahnke, K ^{[1
]}

Fulda, S ^{[1
]}

机构：

[1] Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2003年 / 13卷 / 02期

关键词：

cell death; growth control; hematopoiesis; leukemia; therapy;

D O I：

10.1016/S1044-579X(02)00132-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apoptosis, the cell's intrinsic death program, plays a critical role in the regulation of tissue homeostasis, especially in cell systems with a high turnover rate such as hematopoietic cells. Imbalances between proliferation and cell death may result in premature death, uncontrolled polyclonal or monoclonal expansion or tumor formation. Also, cytotoxic therapy and immunotherapy of leukemia and lymphoma predominantly mediates cell death through induction of apoptosis. Understanding the molecular events by which tumor cells evade apoptotic deletion and which induce apoptosis by cytotoxic therapies, have provided a paradigm to link normal growth control, malignant transformation and response to therapy. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：149 / 158

页数：10

共 111 条

[1] Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-x(L)) but not pro-apoptotic (bax, bcl-x(S)) gene expression [J].