Foliate and DNA methylation during in utero development and aging

被引：53

作者：

McKay, JA ^{[1
]}

Williams, EA

Mathers, JC

机构：

[1] Univ Newcastle Upon Tyne, Sch Clin Med Sci, Human Nutr Res Ctr, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Univ Sheffield, No Gen Hosp, Human Nutr Unit, Sheffield SS 7AU, S Yorkshire, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

aging; cancer; DNA methylation; folate; in utero development;

D O I：

10.1042/BST0321006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. Aberrant DNA methylation has been implicated in the pathogenesis of a number of diseases associated with aging, including cancer and cardiovascular and neurological diseases. Evidence is accumulating that dietary factors in utero modulate disease risk in later life. Although folic acid is a key component of DNA methylation, the impact of folic acid availability in utero on DNA methylation patterns and disease risk in adulthood is at present poorly characterized. This review describes the relationship between folic acid and DNA methylation, and the association between DNA methylation during in utero development and aging.

引用

页码：1006 / 1007

页数：2

共 12 条

[1] Maternal nutrition, fetal nutrition, and disease in later life [J].

Barker, DJP .

NUTRITION, 1997, 13 (09) :807-813

[2] DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation [J].

Finnell, RH ;

Spiegelstein, O ;

Wlodarczyk, B ;

Triplett, A ;

Pogribny, IP ;

Melnyk, S ;

James, JS .

JOURNAL OF NUTRITION, 2002, 132 (08) :2457S-2461S

[3] Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together? [J].

Geiman, TM ;

Robertson, KD .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, 87 (02) :117-125

[4] The role of DNA methylation in mammalian epigenetics [J].

Jones, PA ;

Takai, D .

SCIENCE, 2001, 293 (5532) :1068-1070

[5] TARGETED MUTATION OF THE DNA METHYLTRANSFERASE GENE RESULTS IN EMBRYONIC LETHALITY [J].

LI, E ;

BESTOR, TH ;

JAENISCH, R .

CELL, 1992, 69 (06) :915-926

[6] INHIBITION OF CEPHALIC NEURAL-TUBE CLOSURE BY 5-AZACYTIDINE IN NEURULATING RAT EMBRYOS INVITRO [J].

MATSUDA, M ;

YASUTOMI, M .

ANATOMY AND EMBRYOLOGY, 1992, 185 (03) :217-223

[7] Methylation and acetylation in nervous system development and neurodegenerative disorders [J].

Mattson, MP .

AGEING RESEARCH REVIEWS, 2003, 2 (03) :329-342

[8] Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development [J].

Piedrahita, JA ;

Oetama, B ;

Bennett, GD ;

van Waes, J ;

Kamen, BA ;

Richardson, J ;

Lacey, SW ;

Anderson, RGW ;

Finnell, RH .

NATURE GENETICS, 1999, 23 (02) :228-232

[9] DNA METHYLATION IN EARLY DEVELOPMENT [J].

RAZIN, A ;

SHEMER, R .

HUMAN MOLECULAR GENETICS, 1995, 4 :1751-1755

[10] Impact of aging on DNA methylation [J].

Richardson, B .

AGEING RESEARCH REVIEWS, 2003, 2 (03) :245-261

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