Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy

被引:40
作者
Ruiz-Mateos, E
de la Rosa, R
Franco, JM
Martinez-Moya, M
Rubio, A
Soriano, N
Sanchez-Quijano, A
Lissen, E
Leal, M
机构
[1] Virgen Rocio Univ Hosp, Viral Hepatitis & AIDS Study Grp, Seville, Spain
[2] Virgen Rocio Univ Hosp, Dept Radiol, Seville, Spain
[3] Univ Seville, Dept Med Biochem & Mol Biol, Seville, Spain
关键词
highly active antiretroviral therapy; HIV; IL-7; immune reconstitution; thymus;
D O I
10.1097/00002030-200305020-00002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: Immune reconstitution after highly active antiretroviral therapy (HAART) in HIV-infected patients has led to an increase in the number of new CD4 T lymphocytes. Neolymphopoiesis in the thymus has been proposed as a mechanism in T-cell regeneration. Nevertheless, factors involved in the regeneration of T cells by thymic-dependent pathways in HIV-infected patients under HAART are still unknown and might be of relevance in HIV infection. The aim of this work was to study the role of IL-7 in the thymic rebound of HIV-infected adults under HAART. Design: To study the association between IL-7 and thymic function-related markers, these variables were measured in 49 antiretroviral-naive HIV-infected patients at baseline and at weeks 12, 24, 36 and 48 of treatment. Methods: Thymic function-related markers: thymic volume, naive phenotype, and T-cell receptor excision circles (TREC) bearing-cells, were evaluated by computed tomography, flow cytometry, and quantitative polymerase chain reaction, respectively. IL-7 levels were evaluated using a high sensitivity colorimetric enzyme-linked immunosorbent assay. Results: At baseline, we found an inverse correlation between IL-7 levels and thymic function-associated parameters: thymic volume, naive T cells and TREC-bearing cells. After 48 weeks of therapy increased levels of thymic function-related markers along with a significant decrease in IL-7 levels were found. IL-7 levels at baseline were the only independently associated variable with respect to changes in thymic volume at weeks 12, 24 and 48 of follow-up. Conclusion: These data suggest that IL-7 plays an important role in thymic rebound in adult HIV-infected patients under HAART. (C) 2003 Lippincott Williams Wilkins.
引用
收藏
页码:947 / 954
页数:8
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