Proteins that bind high-mannose sugars of the HIV envelope

被引：81

作者：

Botos, I ^{[1
]}

Wlodawer, A ^{[1
]}

机构：

[1] NCI, Macromol Crystallog Lab, Frederick, MD 21702 USA

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2005年 / 88卷 / 02期

关键词：

gp120; gp41; 2G12; mannose-binding protein; cyanovirin-N;

D O I：

10.1016/j.pbiomolbio.2004.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A broad range of proteins bind high-mannose carbohydrates found on the surface of the envelope protein gp120 of the human immunodeficiency virus and thus interfere with the viral life cycle, providing a potential new way of controlling HIV infection. These proteins interact with the carbohydrate moieties in different ways. A group of them interacts as typical C-type lectins via a Ca2+ ion. Another group interacts with specific single, terminal sugars, without the help of a metal cation. A third group is involved in more intimate interactions, with multiple carbohydrate rings and no metal ion. Finally, there is a group of lectins for which the interaction mode has not yet been elucidated. This review summarizes, principally from a structural point of view, the current state of knowledge about these high-mannose binding proteins and their mode of sugar binding. Published by Elsevier Ltd.

引用

页码：233 / 282

页数：50

共 213 条

[41]

CHILDS RA, 1990, J BIOL CHEM, V265, P20770

[42]

CHRISTOPHER JA, 1998, SPOCK STRUCTURAL PRO

[43] Using conjoined rigid body/torsion angle simulated annealing to determine the relative orientation of covalently linked protein domains from dipolar couplings [J].