Regulation of protein kinases: Controlling activity through activation segment conformation

被引：857

作者：

Nolen, B ^{[1
]}

Taylor, S ^{[1
]}

Ghosh, G ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92116 USA

来源：

MOLECULAR CELL | 2004年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.molcel.2004.08.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the confromation of the activation segment controls kinase activity.

引用

页码：661 / 675

页数：15

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