The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

被引：62

作者：

Engel, David ^{[1
]}

Seijkens, Tom ^{[1
]}

Poggi, Marjorie ^{[1
]}

Sanati, Maryam ^{[2
]}

Thevissen, Larissa ^{[2
]}

Beckers, Linda ^{[1
]}

Wijnands, Erwin ^{[1
]}

Lievens, Dirk ^{[1
]}

Lutgens, Esther ^{[1
,2
]}

机构：

[1] Univ Maastricht, Dept Pathol, CARIM, NL-6229 HX Maastricht, Netherlands

[2] Univ Hosp Aachen, Rhein Westfal TH Aachen, Fac Med, IMCAR, Aachen, Germany

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 05期

关键词：

Atherosclerosis; Inflammation; Co-stimulation; CD40; CD154; TISSUE FACTOR EXPRESSION; SOLUBLE CD40 LIGAND; ENDOTHELIAL-CELLS; INFLAMMATORY RESPONSE; NEOINTIMA FORMATION; CD40-TRAF6; AXIS; UP-REGULATION; IMMUNE; CD154; ATHEROGENESIS;

D O I：

10.1016/j.smim.2009.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful costimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：308 / 312

页数：5

共 57 条

[1] A functional role for inducible costimulator (ICOS) in atherosclerosis [J].

Afek, A ;

Harats, D ;

Roth, A ;

Keren, G ;

George, J .

ATHEROSCLEROSIS, 2005, 183 (01) :57-63

[2] The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells [J].

Ahonen, CL ;

Manning, EM ;

Erickson, LD ;

O'Connor, BP ;

Lind, EF ;

Pullen, SS ;

Kehry, MR ;

Noelle, RJ .

NATURE IMMUNOLOGY, 2002, 3 (05) :451-456

[3] Natural regulatory T cells control the development of atherosclerosis in mice [J].

Ait-Oufella, H ;

Salomon, BL ;

Potteaux, S ;

Robertson, AKL ;

Gourdy, P ;

Zoll, J ;

Merval, R ;

Esposito, B ;

Cohen, JL ;

Fisson, S ;

Flavell, RA ;

Hansson, GK ;

Klatzmann, D ;

Tedgui, A ;

Mallat, Z .

NATURE MEDICINE, 2006, 12 (02) :178-180

[4] CD40L stabilizes arterial thrombi by a β3 integrin-dependent mechanism [J].

André, P ;

Prasad, KSS ;

Denis, CV ;

He, M ;

Papalia, JM ;

Hynes, RO ;

Phillips, DR ;

Wagner, DD .

NATURE MEDICINE, 2002, 8 (03) :247-252

[5] Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling [J].

Arron, JR ;

Pewzner-Jung, Y ;

Walsh, MC ;

Kobayashi, T ;

Choi, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (07) :923-934

[6] Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells [J].

Bavendiek, U ;

Zirlik, A ;

LaClair, S ;

MacFarlane, L ;

Libby, P ;

Schönbeck, U .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (06) :1244-1249

[7] Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor κB, and Egr-1 [J].

Bavendiek, U ;

Libby, P ;

Kilbride, M ;

Reynolds, R ;

Mackman, N ;

Schönbeck, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :25032-25039

[8] B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice [J].

Buono, C ;

Pang, H ;

Uchida, Y ;

Libby, P ;

Sharpe, AH ;

Lichtman, AH .

CIRCULATION, 2004, 109 (16) :2009-2015

[9] Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty [J].

Cipollone, F ;

Ferri, C ;

Desideri, G ;

Paloscia, L ;

Materazzo, G ;

Mascellanti, M ;

Fazia, M ;

Iezzi, A ;

Cuccurullo, C ;

Pini, B ;

Bucci, M ;

Santucci, A ;

Cuccurullo, F ;

Mezzetti, A .

CIRCULATION, 2003, 108 (22) :2776-2782

[10] Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus:: effect of improved metabolic control [J].

Cipollone, F ;

Chiarelli, F ;

Davì, G ;

Ferri, C ;

Desideri, G ;

Fazia, M ;

Iezzi, A ;

Santilli, F ;

Pini, B ;

Cuccurullo, C ;

Tumini, S ;

Del Ponte, A ;

Santucci, A ;

Cuccurullo, F ;

Mezzetti, A .

DIABETOLOGIA, 2005, 48 (06) :1216-1224

← 1 2 3 4 5 6 →