Marine Natural Products: A Source of Novel Anticancer Drugs

被引：425

作者：

Khalifa, Shaden A. M. ^{[1
,2
]}

Elias, Nizar ^{[3
]}

Farag, Mohamed A. ^{[4
,5
]}

Chen, Lei ^{[6
]}

Saeed, Aamer ^{[7
]}

Hegazy, Mohamed-Elamir F. ^{[8
,9
]}

Moustafa, Moustafa S. ^{[10
]}

Abd El-Wahed, Aida ^{[10
]}

Al-Mousawi, Saleh M. ^{[10
]}

Musharraf, Syed G. ^{[11
]}

Chang, Fang-Rong ^{[12
]}

Iwasaki, Arihiro ^{[13
]}

Suenaga, Kiyotake ^{[13
,14
]}

Alajlani, Muaaz ^{[15
]}

Goransson, Ulf ^{[15
]}

El-Seedi, Hesham R. ^{[15
,16
,17
,18
]}

机构：

[1] Karolinska Univ Hosp, Clin Res Ctr, S-14157 Stockholm, Sweden

[2] Stockholm Univ, Dept Mol Biosci, Wenner Gren Inst, SE-10691 Stockholm, Sweden

[3] Univ Kalamoon, Dept Lab Med, Fac Med, POB 222, Dayr Atiyah, Syria

[4] Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St,PB 11562, Cairo, Egypt

[5] Amer Univ Cairo, Dept Chem, Sch Sci & Engn, New Cairo 11835, Egypt

[6] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China

[7] Quaid I Azam Univ, Dept Chemitry, Islamabad 45320, Pakistan

[8] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Staudingerweg 5, D-55128 Mainz, Germany

[9] Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt

[10] Kuwait Univ, Dept Chem, Fac Sci, Safat 13060, Kuwait

[11] Univ Karachi, Int Ctr Chem & Biol Sci ICCBS, HEJ Inst Chem Res, Karachi 75270, Pakistan

[12] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[13] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan

[14] Univ HalleWittenberg, Dept Pharmaceut Biol Pharmacognosy, Inst Pharm, Hoher Weg 8, DE-06120 Halle, Saale, Germany

[15] Uppsala Univ, Dept Med Chem, Pharmacognosy, Box 574, SE-75123 Uppsala, Sweden

[16] Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt

[17] Jiangsu Univ, Coll Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[18] Al Rayan Coll, Al Rayan Res & Innovat Ctr, Medina 42541, Saudi Arabia

来源：

MARINE DRUGS | 2019年 / 17卷 / 09期

基金：

瑞典研究理事会;

关键词：

marine; plants; microorganism; antitumor; anticancer; cytotoxic; clinical trials; drugs; BREAST-CANCER; IN-VIVO; ECTEINASCIDIN-743; ET-743; ABSOLUTE-CONFIGURATION; SECONDARY METABOLITES; PROTEASOME INHIBITOR; ANTITUMOR COMPOUNDS; CELL-PROLIFERATION; CYCLIC-PEPTIDES; BROWN SEAWEED;

D O I：

10.3390/md17090491

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

引用

页数：31

共 216 条

[1]

Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus [J].