Transport of free and N-linked oligomannoside species across the rough endoplasmic reticulum membranes

被引：17

作者：

Cacan, R ^{[1
]}

Verbert, A ^{[1
]}

机构：

[1] Univ Sci & Technol Lille, Chim Biol Lab, CNRS, UMR 8576, F-59655 Villeneuve Dascq, France

来源：

GLYCOBIOLOGY | 2000年 / 10卷 / 07期

关键词：

N-glycosylation; oligomannoside; endoplasmic reticulum; transport;

D O I：

10.1093/glycob/10.7.645

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-glycosylation process occurs in the rough endoplasmic reticulum, It requires the transport of glycosyl donors into the lumen and the exit of the glycosylated products toward the secretory pathway. Besides this main flow, the formation of free oligomannosides, glycopeptides, and misfolded glycoproteins which do not enter the secretory pathway and are cleared out of the endoplasmic reticulum by specific transports has been demonstrated. This review focuses on the export mechanisms of these three side products of the N-glycosylation process and discusses their physiological significance.

引用

页码：645 / 648

页数：4

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