Bioavailability and its assessment

被引：231

作者：

Toutain, PL ^{[1
]}

Bousquet-Mélou, A ^{[1
]}

机构：

[1] ENVT, INRA, UMR Physiopathol & Toxicol Expt 181, F-31076 Toulouse 23, France

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 2004年 / 27卷 / 06期

关键词：

D O I：

10.1111/j.1365-2885.2004.00604.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bioavailability is a key pharmacokinetic parameter which expresses the proportion of a drug administered by any nonvascular route that gains access to the systemic circulation. Presented in this review are the different approaches to measurement of bioavailability (absolute and relative), including the case in which intravenous administration is impossible. The rate of drug absorption is also discussed with special emphasis on the possible difficulties encountered using C-max and T-max or curve fitting to evaluate the rate of drug absorption.

引用

页码：455 / 466

页数：12

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