An uridine derivative containing a hydrophobic fluorescent probe at the 2'-position: Synthesis and its incorporation into oligonucleotides

被引：15

作者：

Yamana, K

Mitsui, T

Hayashi, H

Nakano, H

机构：

[1] Department of Applied Chemistry, Himeji Institute of Technology, Hyogo 671-22, 2167 Shosha, Himeji

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(97)01329-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2'-(6-dimethylamino-2-naphthamide)uridine [U(DAN)] has been described. The nucleoside was converted to the 5'-dimethoxylrityl nucleoside phosphoramidite which could be used for incorporation of U(DAN) into the desired positions of the oligonucleotide sequence. (C) 1997 Elsevier Science Ltd.

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页码：5815 / 5818

页数：4

相关论文

共 8 条

[1]

CHEN RF, 1967, J BIOL CHEM, V242, P5813

[2] Synthesis of alkylphenanthrenes - Part VII 7-hydroxy-l 2-dimethylphenanthrene [J].

Haworth, RD ;

Sheldrick, G .

JOURNAL OF THE CHEMICAL SOCIETY, 1934, :864-867

[3] DYNAMIC TOTAL FLUORESCENCE AND ANISOTROPY DECAY STUDY OF THE DANSYL FLUOROPHOR IN MODEL COMPOUNDS AND ENZYMES [J].

HOENES, G ;

HAUSER, M ;

PFLEIDERER, G .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 43 (02) :133-137

[4] The reaction of iodine with some ketones in the presence of pyridine [J].

King, LC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1944, 66 :894-895

[5] STUDY OF SOLVENT EFFECTS ON FLUORESCENCE OF 1-(DIMETHYLAMINO)-5-NAPHTHALENESULFONIC ACID AND RELATED COMPOUNDS [J].

LI, YH ;

CHAN, LM ;

TYER, L ;

MOODY, RT ;

HIMEL, CM ;

HERCULES, DM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (11) :3118-3126

[6] ESTIMATION OF THE POLARITY OF THE PROTEIN INTERIOR BY OPTICAL SPECTROSCOPY [J].

MACGREGOR, RB ;

WEBER, G .

NATURE, 1986, 319 (6048) :70-73

[7] SYNTHESIS AND SPECTRAL PROPERTIES OF A HYDROPHOBIC FLUORESCENT-PROBE - 6-PROPIONYL-2-(DIMETHYLAMINO)NAPHTHALENE [J].

WEBER, G ;

FARRIS, FJ .

BIOCHEMISTRY, 1979, 18 (14) :3075-3078

[8] Synthesis, binding and fluorescence properties of oligonucleotide derivatives having a dansyl fluorescence label attached to the 2'-position of a ribonucleoside [J].

Yamana, K ;

Ohashi, Y ;

Nunota, K ;

Nakano, H .

TETRAHEDRON, 1997, 53 (12) :4265-4270