A short asymmetric synthesis of 2,5-disubstituted pyrrolidines

被引：23

作者：

Katritzky, AR ^{[1
]}

Cui, XL

Yang, BZ

Steel, PJ

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(98)00134-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to chiral 2,5-disubstituted pyrrolidines, starting from chiral 2-phenylglycinol, 1,5-dimethoxytetrahydrofuran, and benzotriazole, involves the diastereoselective substitution by Grignard reagents of a benzotriazolyl group in a crystalline intermediate obtained in high yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1697 / 1700

页数：4

共 7 条

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