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Multiphoton endoscopy

被引：252
作者：
Jung, JC
Schnitzer, MJ
机构：
[1] Bell Labs, Lucent Technol, Murray Hill, NJ 07974 USA
[2] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
来源：
OPTICS LETTERS | 2003年 / 28卷 / 11期
关键词：
D O I：
10.1364/OL.28.000902
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Despite widespread use of multiphoton fluorescence microscopy, development of endoscopes for nonlinear optical imaging has been stymied by the degradation of ultrashort excitation pulses that occurs within optical fiber as a result of the combined effects of group-velocity dispersion and self-phase modulation. We introduce microendoscopes (350-1000 mum in diameter) based on gradient-index microlenses that effectively eliminate self-phase modulation within the endoscope. Laser-scanning multiphoton fluorescence endoscopy exhibits micrometer-scale resolution. We used multiphoton endoscopes to image fluorescently labeled neurons and dendrites. (C) 2003 Optical Society of America.
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页码：902 / 904
页数：3
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