Mast cells - key effector cells in immune responses

被引：226

作者：

Metz, Martin

Maurer, Marcus ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Dept Dermatol & Allergy, D-10117 Berlin, Germany

[2] Stanford Med Sch, Dept Pathol, Stanford, CA 94305 USA

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 05期

关键词：

D O I：

10.1016/j.it.2007.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells are best known for their potent effector functions in allergic disorders. In recent years, however, mast cells have been identified to be involved in a surprisingly complex range of immune functions that go far beyond allergies and include the development of autoimmune disorders and peripheral tolerance, and the initiation and maintenance of adaptive and innate host responses. Here, we review the key signals and effector mechanisms that have lately been identified for mast cell functions in these immune responses.

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页码：234 / 241

页数：8

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