Ligand bridging of the DNA Holliday junction: Molecular recognition of a stacked-X four-way junction by a small molecule

被引：41

作者：

Brogden, Anna L.

Hopcroft, Nicholas H.

Searcey, Mark

Cardin, Christine J. ^{[1
]}

机构：

[1] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England

[2] Univ London, Sch Pharm, London WC1N 1AX, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 21期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

bridging ligands; DNA structures; ligand design; structure elucidation; X-ray diffraction;

D O I：

10.1002/anie.200603760

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Planning a Holliday: A new mode of binding to a stacked-X, four-way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：3850 / 3854

页数：5

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