Mechanisms of translational control by the 3′ UTR in development and differentiation

被引：275

作者：

de Moor, CH ^{[1
]}

Meijer, H ^{[1
]}

Lissenden, S ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biomed Sci, Ctr Biochem & Cell Biol, Nottingham NG7 2UH, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

3 ' UTR; development and differentiation; cell cycle; gene expression; translation;

D O I：

10.1016/j.semcdb.2004.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Translational control plays a major role in early development, differentiation and the cell cycle. In this review, we focus on the four main mechanisms of translational control by 3' untranslated regions: 1. Cytoplasmic polyadenylation and deadenylation; 2. Recruitment of 4E binding proteins; 3 Regulation of ribosomal subunit binding; 4. Post-initiation repression by microRNAs. Proteins with conserved functions in translational control during development include cytoplasmic polyadenylation element binding proteins (CPEB/Orb), Pumilio, Bruno, Fragile X mental retardation protein and RNA helicases. The translational regulation of the mRNAs encoding cyclin B1, Oskar, Nanos, Male specific lethal 2 (Msl-2), lipoxygenase and Lin-14 is discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：49 / 58

页数：10

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