Highly stereoselective synthesis of the indolo[2,3-a]quinolizine ring system and application to indole natural product synthesis

被引：35

作者：

Allin, SM ^{[1
]}

Thomas, CI

Allard, JE

Doyle, K

Elsegood, MRJ

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] OSI Pharmaceut, Oxford OX4 6LT, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 38期

关键词：

D O I：

10.1016/j.tetlet.2004.07.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a novel, facile and highly stereoselective approach to the indolo[2,3-a]quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis through conversion of the template to a simple indole alkaloid with high enantiomeric purity. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7103 / 7105

页数：3

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