Current approaches and perspectives in human keratinocyte-based gene therapies

被引：18

作者：

Del Rio, M

Gache, Y

Jorcano, JL

Meneguzzi, G

Larcher, F

机构：

[1] CIEMAT, Epithelial Damage Repair & Tissue Engn Project, E-28040 Madrid, Spain

[2] Fdn Marselino Botin Gene Therapy, INSERM, U634, Fac Med, Nice, France

来源：

GENE THERAPY | 2004年 / 11卷 / Suppl 1期

关键词：

skin; gene transfer; tissue engineering; stem cells;

D O I：

10.1038/sj.gt.3302370

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inherited and acquired disorders are liable to treatment with somatic gene therapy. The skin, and in particular epidermal cells, are particularly suited to genetic manipulation and follow-up of therapeutic effects. Cutaneous gene therapy may be effective for skin defects and systemic abnormalities. The robust basic and preclinical data available today would support the application of keratinocyte-based gene therapy to patients.

引用

收藏

页码：S57 / S63

页数：7

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