miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit

被引:37
作者
Feng, Min [1 ]
Yu, Qiang [1 ]
机构
[1] ASTAR, Genome Inst Singapore, Biopolis, Singapore
关键词
cancer; epigenetics; miR-449; E2F1; DZNep; APOPTOSIS; CANCER;
D O I
10.4161/cc.9.2.10502
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:213 / 214
页数:2
相关论文
共 9 条
[1]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[2]   A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].
Bernstein, BE ;
Mikkelsen, TS ;
Xie, XH ;
Kamal, M ;
Huebert, DJ ;
Cuff, J ;
Fry, B ;
Meissner, A ;
Wernig, M ;
Plath, K ;
Jaenisch, R ;
Wagschal, A ;
Feil, R ;
Schreiber, SL ;
Lander, ES .
CELL, 2006, 125 (02) :315-326
[3]   DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications [J].
Jiang, Xia ;
Tan, Jing ;
Li, Jingsong ;
Kivimaee, Saul ;
Yang, Xiaojing ;
Zhuang, Li ;
Lee, Puay Leng ;
Chan, Mark T. W. ;
Stanton, Lawrence W. ;
Liu, Edison T. ;
Cheyette, Benjamin N. R. ;
Yu, Qiang .
CANCER CELL, 2008, 13 (06) :529-541
[4]   E2F1-regulated microRNAs impair TGFβ-dependent cell-cycle arrest and apoptosis in gastric cancer [J].
Petrocca, Fabio ;
Visone, Rosa ;
Onelli, Mariadele Rapazzotti ;
Shah, Manisha H. ;
Nicoloso, Milena S. ;
de Martino, Ivana ;
Iliopoulos, Dimitrios ;
Pilozzi, Emanuela ;
Liu, Chang-Gong ;
Negrini, Massimo ;
Cavazzini, Luigi ;
Volinia, Stefano ;
Alder, Hansjuerg ;
Ruco, Luigi P. ;
Baldassarre, Gustavo ;
Croce, Carlo M. ;
Vecchione, Andrea .
CANCER CELL, 2008, 13 (03) :272-286
[5]   miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression [J].
Pickering, M. T. ;
Stadler, B. M. ;
Kowalik, T. F. .
ONCOGENE, 2009, 28 (01) :140-145
[6]   Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells [J].
Tan, Jing ;
Yang, Xiaojing ;
Zhuang, Li ;
Jiang, Xia ;
Chen, Wei ;
Lee, Puay Leng ;
Karuturi, R. K. Murthy ;
Tan, Patrick Boon Ooi ;
Liu, Edison T. ;
Yu, Qiang .
GENES & DEVELOPMENT, 2007, 21 (09) :1050-1063
[7]   Sibling rivalry in the E2F family [J].
Trimarchi, JM ;
Lees, JA .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (01) :11-20
[8]   miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A [J].
Yang, Xiaojing ;
Feng, Min ;
Jiang, Xia ;
Wu, Zhenlong ;
Li, Zhimei ;
Aau, Meiyee ;
Yu, Qiang .
GENES & DEVELOPMENT, 2009, 23 (20) :2388-2393
[9]   CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells [J].
Yang, Xiaojing ;
Karuturi, R. K. Murthy ;
Sun, Feng ;
Aau, Meiyee ;
Yu, Kun ;
Shao, Rongguang ;
Miller, Lance D. ;
Tan, Patrick Boon Ooi ;
Yu, Qiang .
PLOS ONE, 2009, 4 (04)