Association of Anxiety and Depression With Microtubule-Associated Protein 2-and Synaptopodin-Immunolabeled Dendrite and Spine Densities in Hippocampal CA3 of Older Humans

被引:94
作者
Soetanto, Ainie
Wilson, Robert S. [2 ]
Talbot, Konrad
Un, Ashley
Schneider, Julie A. [2 ]
Sobiesk, Mark [3 ]
Kelly, Jeremiah [2 ]
Leurgans, Sue [2 ]
Bennett, David A. [2 ]
Arnold, Steven E. [1 ]
机构
[1] Univ Penn, Ctr Neurobiol & Behav, Translat Res Labs 2205, Cellular & Mol Neuropathol Program,Dept Psychiat, Philadelphia, PA 19104 USA
[2] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA
[3] Phase 3 Imaging, Glen Mills, PA USA
关键词
MILD COGNITIVE IMPAIRMENT; CHRONIC PSYCHOSOCIAL STRESS; MOSSY FIBER SYNAPSES; ALZHEIMER-DISEASE; NEUROFIBRILLARY TANGLES; PSYCHOLOGICAL DISTRESS; PYRAMIDAL NEURONS; APICAL DENDRITES; INDUCED ATROPHY; SPATIAL MEMORY;
D O I
10.1001/archgenpsychiatry.2010.48
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Context: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines. Objectives: To examine whether analogous distress-related neuroanatomic changes occur in humans and whether such changes might also be related to cognitive dysfunction observed in older people who report greater psychological distress. Design: Postmortem study of brain tissues from participants of the Religious Orders Study, an ongoing population-based clinicopathological study of aging and cognition. Setting: The Rush University Religious Orders Study and the University of Pennsylvania Cellular and Molecular Neuropathology Program. Participants: Seventy-two deceased participants of the Religious Orders Study. Main Outcome Measures: Densities of microtubule-associated protein 2-immunolabeled dendrites and synaptopodin-immunolabeled dendritic spines in the CA3 subfield of the hippocampus, quantified using semiautomated image acquisition and analysis. Results: Higher levels of trait anxiety and longitudinal depression scores were associated with decreased densities of dendrites and spines in CA3. Dendrite and spine densities did not correlate with an index of global cognition or with densities of common age-related pathological changes. Conclusions: Regressive neuronal changes occur in humans who experience greater psychological distress. These changes are analogous to neuronal changes in animal models of chronic stress.
引用
收藏
页码:448 / 457
页数:10
相关论文
共 86 条
[1]  
Amaral D.G., 1990, The human Nervous System, P711
[2]   The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].
Arnold, Steven E. ;
Hyman, Bradley T. ;
Flory, Jill ;
Damasio, Antonio R. ;
Van Hoesen, Gary W. .
CEREBRAL CORTEX, 1991, 1 (01) :103-116
[3]  
Benes FM, 1996, SYNAPSE, V22, P338
[4]  
Benes FM, 2001, HIPPOCAMPUS, V11, P482, DOI 10.1002/hipo.1065
[5]  
Bennett D. A., 2005, Neurology, V64, P834
[6]   Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people [J].
Bennett, DA ;
Schneider, JA ;
Wilson, RS ;
Bienias, JL ;
Berry-Kravis, E ;
Arnold, SE .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2005, 76 (09) :1194-1199
[7]   Education modifies the association of amyloid but not tangles with cognitive function [J].
Bennett, DA ;
Schneider, JA ;
Wilson, RS ;
Bienias, JL ;
Arnold, SE .
NEUROLOGY, 2005, 65 (06) :953-955
[8]   Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function [J].
Bennett, DA ;
Schneider, JA ;
Wilson, RS ;
Bienias, JL ;
Arnold, SE .
ARCHIVES OF NEUROLOGY, 2004, 61 (03) :378-384
[9]   Postmortem indices linking risk factors to cognition - Results from the religious order study and the memory and aging project [J].
Bennett, David A. .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2006, 20 (03) :S63-S68
[10]  
BODNOFF SR, 1995, J NEUROSCI, V15, P61