Multiple elements within the Xic regulate random X inactivation in mice

被引：30

作者：

Clerc, P ^{[1
]}

Avner, P ^{[1
]}

机构：

[1] Inst Pasteur, F-75015 Paris, France

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 01期

关键词：

X-chromosome; Xist RNA; silencing; antisense transcription; Xic;

D O I：

10.1016/S1084-9521(02)00140-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In female mammals, the majority of the genes on one of the two X-chromosomes are silenced by a process referred to as X-chromosome inactivation. The X-mactivation center (Xic), a complex genomic region on the X-chromosome which controls this process, contains the Xist gene encoding an untranslated RNA which plays a central role in the establishment of the transcriptional repression. The Xic encrypts a sophisticated program which coordinates X inactivation with sex and embryonic development. The present article reviews our current knowledge of the regulatory elements lying within the mouse Xic and of the mechanisms underlying random X inactivation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：85 / 92

页数：8

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