Bone loss in inflammatory disorders

被引：298

作者：

Hardy, R. ^{[1
]}

Cooper, M. S. ^{[1
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, Sch Clin & Expt Med, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2009年 / 201卷 / 03期

关键词：

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; RECEPTOR-RELATED PROTEIN-5; NECROSIS-FACTOR-ALPHA; VITAMIN-D-RECEPTOR; KAPPA-B LIGAND; RHEUMATOID-ARTHRITIS; MINERAL DENSITY; OSTEOCLAST DIFFERENTIATION; OSTEOPROTEGERIN LIGAND;

D O I：

10.1677/JOE-08-0568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic inflammatory diseases of almost any cause are associated with bone loss. Bone loss is due to direct effects of inflammation, poor nutrition, reduced lean body mass, immobility and the effects of treatments, especially glucocorticoids. These mechanisnis are complex and interrelated but are ultimately mediated through effects oil the bone remodelling cycle. Inflammatory disease call increase bone resorption, decrease bone formation but most commonly impacts on both of these processes resulting in all uncoupling of bone formation from resorption in favour of excess resorption. This review will illustrate these interactions between inflammation and bone metabolism and discuss how these are, and might be, manipulated as therapies for inflammation related bone loss. Journal of Endocrinology (2009) 201, 309-320

引用

页码：309 / 320

页数：12

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