Wnt signaling: An embarrassment of receptors

被引：63

作者：

Bejsovec, A ^{[1
]}

机构：

[1] Duke Univ, Dept Biol, Durham, NC 27708 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 24期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-9822(00)00852-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co receptors for Wnt ligands.

引用

页码：R919 / R922

页数：4

共 18 条

[1] A new member of the frizzled family from Drosophila functions as a Wingless receptor
Bhanot, P
Brink, M
Samos, CH
Hsieh, JC
Wang, YS
Macke, JP
Andrew, D
Nathans, J
Nusse, R
[J]. NATURE, 1996, 382 (6588) : 225 - 230
[2] Bhanot P, 1999, DEVELOPMENT, V126, P4175
[3] Binari RC, 1997, DEVELOPMENT, V124, P2623
[4] Chen CM, 1999, DEVELOPMENT, V126, P5441
[5] DROSOPHILA WINGLESS GENERATES CELL TYPE DIVERSITY AMONG ENGRAILED EXPRESSING CELLS
DOUGAN, S
DINARDO, S
[J]. NATURE, 1992, 360 (6402) : 347 - 350
[6] HAECKER U, 1997, DEVELOPMENT, V124, P3565
[7] A member of the frizzled protein family mediating axis induction by Wnt-5A
He, X
SaintJeannet, JP
Wang, YS
Nathans, J
Dawid, I
Varmus, H
[J]. SCIENCE, 1997, 275 (5306) : 1652 - 1654
[8] Cloning of a novel member of the low-density lipoprotein receptor family
Hey, PJ
Twells, RCJ
Phillips, MS
Nakagawa, Y
Brown, SD
Kawaguchi, Y
Cox, R
Xie, GC
Dugan, V
Hammond, H
Metzker, ML
Todd, JA
Hess, JF
[J]. GENE, 1998, 216 (01) : 103 - 111
[9] Daily cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
Lin, XH
Perrimon, N
[J]. NATURE, 1999, 400 (6741) : 281 - 284
[10] Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction
Moline, MM
Dierick, HA
Southern, C
Bejsovec, A
[J]. CURRENT BIOLOGY, 2000, 10 (18) : 1127 - 1130

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