Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue

被引：36

作者：

Tang, RB

Wang, HY

Lu, HY

Xiong, J

Li, HH

Qiu, XH

Liu, HQ ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Histol & Embryol, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Eastern Hepatobiliary Surg Inst, Shanghai 200433, Peoples R China

来源：

MOLECULAR CARCINOGENESIS | 2005年 / 42卷 / 02期

关键词：

Alu elements; transcription; hepatocellular carcinoma;

D O I：

10.1002/mc.20057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There have been extensive observations that RNA containing repetitive elements accumulates in transformed cells and tumor tissues. In the present study, we first obtained result consistent with previous observations by in situ hybridization. Then we used primer extension analysis to determine the level of polymerase III directed Alu RNA and found an increased expression of Alu RNA in hepatocellular carcinoma. (C) 2004 Wiley-Liss, Inc.

引用

收藏

页码：93 / 96

页数：4

相关论文

共 25 条

[1] Cis-acting influences on Alu RNA levels [J].

Alemán, C ;

Roy-Engel, AM ;

Shaikh, TH ;

Deininger, PL .

NUCLEIC ACIDS RESEARCH, 2000, 28 (23) :4755-4761

[2]

AUGENLICHT LH, 1984, J BIOL CHEM, V259, P1842

[3] MESSENGER-RNA IN HUMAN-CELLS CONTAINS SEQUENCES COMPLEMENTARY TO THE ALU FAMILY OF REPEATED DNA [J].

CALABRETTA, B ;

ROBBERSON, DL ;

MAIZEL, AL ;

SAUNDERS, GF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6003-6007

[4]

CHEN JS, 1995, CANCER RES, V55, P174

[5] Potential Alu function: Regulation of the activity of double-stranded RNA-activated kinase PKR [J].

Chu, WM ;

Ballard, R ;

Carpick, BW ;

Williams, BRG ;

Schmid, CW .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) :58-68

[6]

Clawson GA, 1996, CELL GROWTH DIFFER, V7, P635

[7] DNA methylation in cancer: too much, but also too little [J].

Ehrlich, M .

ONCOGENE, 2002, 21 (35) :5400-5413

[8] ANALYSIS OF TRANSCRIPTION OF THE HUMAN ALU FAMILY UBIQUITOUS REPEATING ELEMENT BY EUKARYOTIC RNA POLYMERASE-III [J].

FUHRMAN, SA ;

DEININGER, PL ;

LAPORTE, P ;

FRIEDMANN, T ;

GEIDUSCHEK, EP .

NUCLEIC ACIDS RESEARCH, 1981, 9 (23) :6439-6456

[9] A ROLE FOR ID REPETITIVE SEQUENCES IN GROWTH-DEPENDENT AND TRANSFORMATION-DEPENDENT REGULATION OF GENE-EXPRESSION IN RAT FIBROBLASTS [J].

GLAICHENHAUS, N ;

CUZIN, F .

CELL, 1987, 50 (07) :1081-1089

[10] SRP-RNA SEQUENCE ALIGNMENT AND SECONDARY STRUCTURE [J].

LARSEN, N ;

ZWIEB, C .

NUCLEIC ACIDS RESEARCH, 1991, 19 (02) :209-215