Direct versatile route to conformationally constrained glutamate analogues

被引：20

作者：

Dyer, J

Keeling, S

Moloney, MG

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 04期

关键词：

D O I：

10.1039/a708429c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; variations in the C(2)H-C(3)H coupling constants were observed depending upon the nature of remote substituents on the heterocyclic ring, consistent with modification of the ring conformation.

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收藏

页码：461 / 462

页数：2

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